Annotation Data Overview
Data that are provided for each case include tumor size, TNM stage, number of nodes positive, tumor grade, age at diagnosis and race.
NOTE: The CDP breast progression TMA is not designed to have good power to examine associations with survival. Survival data are provided for the cases on this TMA as a service, but users are cautioned that this data was not considered in the overall design of the TMA.
| Data Variable | Description | Coding |
|---|---|---|
| Case Type | Identifies type of tissue | Text (Invasive, DCIS, normal breast, normal non-breast, cell line) |
| Race | Race of patient | Text or blank (White, Black, American Indian, Asian, Unknown) |
| Age | Age at initial diagnosis | Integer or blank |
| T Stage | AJCC (version 5) T stage | TIS = Carcinoma In-situ T1 = Tumor < 20 mm T1a = Tumor < 5 mm T1b = Tumor > 5 mm and < 10 mm= T1c = Tumor > 10 mm and < 20 mm T2 = Tumor > 20 mm and < 50 mm T3 = Tumor > 50 mm T4 = Tumor any size + extension T4a = Extension to chest wall T4b = Edema or ulceration or satellite skin nodules T4c = Both T4a and T4b T4d = Inflammatory carcinoma Blank |
| N Stage | AJCC (version 5) N stage | NX = Minimum req. not met (unknown) N0 = No evidence of regional LN involvement N1 = Mets to movable, ipsilateral node N1a = Only micromets (< 2 mm) N1b = Any nodal mets > 2 mm N1b1 = Mets to 1-3 nodes, any > 2 mm and all < 20 mm N1b2 = Mets to= 4 or mor nodes any > 2 mm and all < 20 mm N1b3 = Extension of tumor beyond node capsule and < 20 mm N1b4 = Mets to nodes > 20 mm N2 = Mets to ipsilateral nodes that are fixed to one another or to other structures N3 = Mets to ipsilateral internal mammary lymph node Blank |
| M Stage | AJCC (version 5) M stage | MX = Distant mets not assessed M0 = No known distant mets M1 = Distant mets present Blank |
| Number of Nodes Positive | Number of nodes positive at initial diagnosis | Integer or blank |
| Size of Invasive Cancer in cm | Measurement (in cm) of the longest diameter of the tumor | Integer or blank |
| ER Score | ASCO CAP Guidelines for ER Scoring | 0 = Negative (< 1% expressing cells) 1 = Positive (= 1% expressing cells) NA = Not applicable |
| PR Score | ASCO CAP Guidelines for PR Scoring | 0 = Negative (< 1% expressing cells) 1 = Positive (= 1% expressing cells NA = Not applicable |
| HER2 IHC | ASCO CAP Guidelines for HER2 Scoring | 0 = No staining 1 = Weak, incomplete membrane staining in any proportion of invasive tumor cells, or weak, complete membrane staining in less than 10% of cells. 2 = Complete membrane staining that is non-uniform or weak but with obvious circumferential distribution in at least 10% of cells, or intense complete membrane staining in 30% or less of tumor cells. 3 = Uniform intense membrane staining of more than 30% of invasive tumor cells. NA = Not applicable |
| HER2 FISH | ASCO CAP Guidelines for HER2 Scoring | 0 = Not amplified 1 = Amplified |
| HER2 Score | Final HER2 result that is a combination of the HER2 IHC and FISH evaluations. HER2 FISH was performed for all 1+ and 2+ HER2 IHC results. | 0 = Negative: IHC Score 0; or IHC Score 1+ or 2+ and HER2 not amplified with FISH 1 = Positive: IHC score 3+; or IHC Score 1+ or 2+ and HER2 amplified with FISH |
| Total Score | Histologic grade of case | 1 = Grade I 2 = Grade II 3 = Grade III Blank |
| Vital Status | Vital status at last contact. Obtained from administrative records, physician notes, or death certificate. | Alive Decesased |
| Survival Time in Months | Number of months from breast cancer diagnosis to death, if known, or to date last known alive. | Numeric |
| Invasive Link | Coordinates if specimen is matched to an invasive specimen that appears elsewhere on the array | Alphanumeric text or blank |
Array Maps, Annotation Keys and Datafiles
Below are downloadable files containing the complete annotation data for these TMAs. No additional data is available. Please contact the Mid-Atlantic Division with any questions.
- Download Annotation Data Key (pdf)
- Download ER/PR/Her2 IHC & FISH staining info (pdf)
- Download Full Annotation Data, Maps, & Scoresheets (MS Excel)