Cancer Diagnosis Program (CDP) Breast Cancer Stage III Prognostic TMA

The CDP 2008 Series Stage III Prognostic TMA represents a collection of 181 stage III non-metastatic breast cancer tissue specimens with associated clinico-pathologic data and clinical follow-up information. These cases are divided into two non-overlapping case sets. The case sets are labeled case sets 18-19 to distinguish them from case sets used on previous TMAs. Each case set is arrayed in quadruplicate, producing a total of 8 TMA blocks. The table below gives the distribution of breast tissue and control samples across the 2 case sets. The number of cores represented on any single TMA section is 118-119 (98-99 breast tissue cores + 20 control cores). Normal breast epithelium cores will be 1.0 mm and all other cores will be 0.6 mm in diameter. An applicant whose request for the Stage III Prognostic TMA is approved would be required to accept TMAs from both case sets, with a minimum of two sections (from different replicate blocks) from each case set. Thus, the minimum number of TMA sections that any investigator would receive is four (2 case sets × 2 replicate TMA blocks per case set × 1 section per TMA block).

TMA Map

Cancer Diagnosis Program (CDP) Breast Cancer Stage III Prognostic TMA Map

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Breast Stage III Prognostic TMA Tissue List

Specimens represented in the CDP 2008 Series Stage III Prognostic TMA case sets. Each case set is used to produce quadruplicate TMA blocks, so numbers presented in table should be multiplied by four to obtain the number of cores required for the full Stage III TMA set.

Type of Case Case Set 18 Case Set 19 Total
Stage III invasive breast carcinoma 91 90 181
Normal breast epithelium 5 5 10
Breast fibroadenoma 3 3 6
Total distinct breast tissue specimens 99 98 197
 

Cell line controls

MCF-7

2 2 4

MCF-10A

2 2 4

SK-BR-3

2 2 4

SK-OV-3

2 2 4

T-47D

2 2 4
 

Normal non-breast tissue controls

Salivary gland

2 2 4

Endometrium

2 2 4

Colon

2 2 4

Tonsil

2 2 4

Prostate

2 2 4
Total controls cores per replicate TMA block 20 20 40
Grand total cores per replicate TMA block 119 118 237
These numbers represent the number of cases selected in the original design of the TMA. Due to the non-uniformity inherent to tissue samples and histologic techniques, not all cases will be represented in all of the TMA sections.

Annotation Data

View and Download TMA Data (Annotation Tables, Maps, Data Key)

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