CHTN_CRC2 - Colorectal Carcinoma Progression

TMA Map

CHTN_CRC2 - Colorectal Carcinoma Progression TMA Map

Code Key

Code Tissue type # of cases*
 
Bnc normal non-neoplastic colonic mucosa from non-cancer cases 7
Bc normal non-neoplastic colonic mucosa from cancer cases 7
Bi inflamed and/or regenerative non-neoplastic mucosa (ulcerative colitis) 7
AS adenomas, < 2 cm in maximum dimension 7
AL adenomas, > 2 cm in maximum dimension 7
CE primary invasive adenocarcinoma, pathologic stage T1 or T2 7
CL primary invasive adenocarcinoma, pathologic stage T3 or T4 8
LN colorectal adenocarcinoma metastatic to lymph nodes, same cases as CL primary cancers 7
M colorectal adenocarcinoma metastatic to distant sites 7
 
Con1 Spleen (control tissue)  
Con2 Kidney (control tissue)  
Con3 Placenta (control tissue)  
Con4 Liver (control tissue)  
 

*This number represents the number of cases selected in the original design of the TMA. Due to the non-uniformity inherent to tissue samples and histologic techniques, not all cases will be represented in all of the TMA sections. In quality assurance assessment of the TMA sections, a minimum of10 cases each of non-neoplastic mucosa, adenoma, primary carcinoma, and metastatic tumor must be present in at least one tissue spot.

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Tissue List

TMA code Diagnosis Location in Colon Gender Age pT stage* pN stage* Grade* Metastatic Site Other samples from same subject
Bnc1 diverticulosis D M 68 NA NA NA NA  
Bnc2 diverticulosis D M 66 NA NA NA NA  
Bnc3 diverticulosis D F 75 NA NA NA NA  
Bnc4 diverticulosis D F 47 NA NA NA NA  
Bnc5 diverticulosis D F 48 NA NA NA NA  
Bnc6 diverticulosis D M 39 NA NA NA NA  
Bnc7 diverticulosis D M 44 NA NA NA NA  
Bc1 mucosa adjacent to adenocarcinoma D F 68 NA NA NA NA CL1
Bc2 mucosa adjacent to adenocarcinoma D M 68 NA NA NA NA CE3, LN3
Bc3 mucosa adjacent to adenocarcinoma D M 56 NA NA NA NA CL3, LN4
Bc4 mucosa adjacent to adenocarcinoma P M 61 NA NA NA NA CL4, LN2
Bc5 mucosa adjacent to adenocarcinoma P M 72 NA NA NA NA CL5
Bc6 mucosa adjacent to adenocarcinoma D F 60 NA NA NA NA CE1
Bc7 mucosa adjacent to adenocarcinoma D M 71 NA NA NA NA CL2, AS7, LN1
Bi1 ulcerative colitis D M 71 NA NA NA NA  
Bi2 ulcerative colitis D M 10 NA NA NA NA  
Bi3 ulcerative colitis D F 54 NA NA NA NA  
Bi4 ulcerative colitis D F 19 NA NA NA NA  
Bi5 ulcerative colitis D M 40 NA NA NA NA  
Bi6 ulcerative colitis P F 53 NA NA NA NA  
Bi7 ulcerative colitis P F 25 NA NA NA NA  
AS1 tubulovillous adenoma D F 47 NA NA NA NA  
AS2 tubulovillous adenoma U M 71 NA NA NA NA  
AS3 tubular adenoma D F 57 NA NA NA NA  
AS4 tubular adenoma P F 60 NA NA NA NA  
AS5 tubular adenoma U M 50 NA NA NA NA  
AS6 tubulovillous adenoma U F 70 NA NA NA NA  
AS7 tubulovillous adenoma D M 71 NA NA NA NA Bc7, CL2, LN1
AL1 tubulovillous adenoma P M 63 NA NA NA NA  
AL2 tubulovillous adenoma D F 71 NA NA NA NA  
AL3 tubulovillous adenoma D M 50 NA NA NA NA  
AL4 tubulovillous adenoma D F 83 NA NA NA NA  
AL5 tubulovillous adenoma D M 54 NA NA NA NA  
AL6 tubulovillous adenoma D F 78 NA NA NA NA  
AL7 tubulovillous adenoma U F 45 NA NA NA NA  
CE1 adenocarcinoma P F 60 pT1 pN0 G2 NA Bc6
CE2 adenocarcinoma D F 29 pT2 pN0 G2 NA  
CE3 adenocarcinoma D M 68 pT2 pN1a G2 NA Bc2, LN3
CE4 adenocarcinoma D M 70 pT2 pN0 G2 NA  
CE5 adenocarcinoma U M 51 pT1 pN0 G1 NA  
CE6 adenocarcinoma P M 62 pT2 pNx G2 NA  
CE7 adenocarcinoma P M 66 pT2 pN0 G2 NA  
CL1 adenocarcinoma D F 68 pT4b pN0 G2 NA Bc1
CL2 adenocarcinoma P M 71 pT3 pN2 G2 NA Bc7
CL3 adenocarcinoma D M 56 pT3 pN1a G2 NA Bc3, LN4
CL4 adenocarcinoma D M 61 pT3 pN2b G2 NA Bc4, LN2
CL5 adenocarcinoma D M 72 pT3 pN0 G2 NA Bc5
CL6 adenocarcinoma P F 70 pT3 pN1b G3 NA  
CL7 adenocarcinoma P F 69 pT3 pN1a G2 NA  
CL8 adenocarcinoma D M 61 pT4b pN1b G3 NA  
LN1 metastatic adenocarcinoma NA M 71 pT3 pN2b G2 lymph node Bc7, CL2, AS7
LN2 metastatic adenocarcinoma NA M 61 pT3 pN2b G2 lymph node Bc4, CL4
LN3 metastatic adenocarcinoma NA M 68 pT2 pN1a G2 lymph node Bc2, CE3
LN4 metastatic adenocarcinoma NA M 56 pT4b pN1a G2 lymph node Bc3, CL3
LN5 metastatic adenocarcinoma NA M 48 pT3 pN2b G2 lymph node M6
LN6 metastatic adenocarcinoma NA M 51 pT4b pN1a G3 lymph node  
LN7 metastatic adenocarcinoma NA M 58 pT4b pN1b G2 lymph node  
M1 metastatic adenocarcinoma NA M 59 pT4b pN2a G3 liver  
M2 metastatic adenocarcinoma NA F 61 pT4a pN1a G2 pelvic soft tissue  
M3 metastatic adenocarcinoma NA F 71 pT4b pN1b G3 liver  
M4 metastatic adenocarcinoma NA F 52 pT4b pNx G2 liver  
M5 metastatic adenocarcinoma NA M 58 pT4b pNx G2 liver  
M6 metastatic adenocarcinoma NA M 48 pT3 pN2b G2 liver LN5
M7 metastatic adenocarcinoma NA M 52 pT3 pN1 G2 liver  
 
 
  *American Joint Committee on Cancer Cancer Staging Manual, 7th Ed.
 
  P = proximal (cecum, ascending, transverse colon), D = distal (descending, sigmoid colon & rectum), U = unknown, N/A = not applicable

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