Mid-Atlantic Division
CHTN_CRC2 - Colorectal Carcinoma Progression
TMA Map
Code Key
| Code | Tissue type | # of cases* |
|---|---|---|
| Bnc | normal non-neoplastic colonic mucosa from non-cancer cases | 7 |
| Bc | normal non-neoplastic colonic mucosa from cancer cases | 7 |
| Bi | inflamed and/or regenerative non-neoplastic mucosa (ulcerative colitis) | 7 |
| AS | adenomas, < 2 cm in maximum dimension | 7 |
| AL | adenomas, > 2 cm in maximum dimension | 7 |
| CE | primary invasive adenocarcinoma, pathologic stage T1 or T2 | 7 |
| CL | primary invasive adenocarcinoma, pathologic stage T3 or T4 | 8 |
| LN | colorectal adenocarcinoma metastatic to lymph nodes, same cases as CL primary cancers | 7 |
| M | colorectal adenocarcinoma metastatic to distant sites | 7 |
| Con1 | Spleen (control tissue) | |
| Con2 | Kidney (control tissue) | |
| Con3 | Placenta (control tissue) | |
| Con4 | Liver (control tissue) | |
|
*This number represents the number of cases selected in the original design of the TMA. Due to the non-uniformity inherent to tissue samples and histologic techniques, not all cases will be represented in all of the TMA sections. In quality assurance assessment of the TMA sections, a minimum of10 cases each of non-neoplastic mucosa, adenoma, primary carcinoma, and metastatic tumor must be present in at least one tissue spot. |
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Tissue List
| TMA code | Diagnosis | Location in Colon† | Gender | Age | pT stage* | pN stage* | Grade* | Metastatic Site | Other samples from same subject |
|---|---|---|---|---|---|---|---|---|---|
| Bnc1 | diverticulosis | D | M | 68 | NA | NA | NA | NA | |
| Bnc2 | diverticulosis | D | M | 66 | NA | NA | NA | NA | |
| Bnc3 | diverticulosis | D | F | 75 | NA | NA | NA | NA | |
| Bnc4 | diverticulosis | D | F | 47 | NA | NA | NA | NA | |
| Bnc5 | diverticulosis | D | F | 48 | NA | NA | NA | NA | |
| Bnc6 | diverticulosis | D | M | 39 | NA | NA | NA | NA | |
| Bnc7 | diverticulosis | D | M | 44 | NA | NA | NA | NA | |
| Bc1 | mucosa adjacent to adenocarcinoma | D | F | 68 | NA | NA | NA | NA | CL1 |
| Bc2 | mucosa adjacent to adenocarcinoma | D | M | 68 | NA | NA | NA | NA | CE3, LN3 |
| Bc3 | mucosa adjacent to adenocarcinoma | D | M | 56 | NA | NA | NA | NA | CL3, LN4 |
| Bc4 | mucosa adjacent to adenocarcinoma | P | M | 61 | NA | NA | NA | NA | CL4, LN2 |
| Bc5 | mucosa adjacent to adenocarcinoma | P | M | 72 | NA | NA | NA | NA | CL5 |
| Bc6 | mucosa adjacent to adenocarcinoma | D | F | 60 | NA | NA | NA | NA | CE1 |
| Bc7 | mucosa adjacent to adenocarcinoma | D | M | 71 | NA | NA | NA | NA | CL2, AS7, LN1 |
| Bi1 | ulcerative colitis | D | M | 71 | NA | NA | NA | NA | |
| Bi2 | ulcerative colitis | D | M | 10 | NA | NA | NA | NA | |
| Bi3 | ulcerative colitis | D | F | 54 | NA | NA | NA | NA | |
| Bi4 | ulcerative colitis | D | F | 19 | NA | NA | NA | NA | |
| Bi5 | ulcerative colitis | D | M | 40 | NA | NA | NA | NA | |
| Bi6 | ulcerative colitis | P | F | 53 | NA | NA | NA | NA | |
| Bi7 | ulcerative colitis | P | F | 25 | NA | NA | NA | NA | |
| AS1 | tubulovillous adenoma | D | F | 47 | NA | NA | NA | NA | |
| AS2 | tubulovillous adenoma | U | M | 71 | NA | NA | NA | NA | |
| AS3 | tubular adenoma | D | F | 57 | NA | NA | NA | NA | |
| AS4 | tubular adenoma | P | F | 60 | NA | NA | NA | NA | |
| AS5 | tubular adenoma | U | M | 50 | NA | NA | NA | NA | |
| AS6 | tubulovillous adenoma | U | F | 70 | NA | NA | NA | NA | |
| AS7 | tubulovillous adenoma | D | M | 71 | NA | NA | NA | NA | Bc7, CL2, LN1 |
| AL1 | tubulovillous adenoma | P | M | 63 | NA | NA | NA | NA | |
| AL2 | tubulovillous adenoma | D | F | 71 | NA | NA | NA | NA | |
| AL3 | tubulovillous adenoma | D | M | 50 | NA | NA | NA | NA | |
| AL4 | tubulovillous adenoma | D | F | 83 | NA | NA | NA | NA | |
| AL5 | tubulovillous adenoma | D | M | 54 | NA | NA | NA | NA | |
| AL6 | tubulovillous adenoma | D | F | 78 | NA | NA | NA | NA | |
| AL7 | tubulovillous adenoma | U | F | 45 | NA | NA | NA | NA | |
| CE1 | adenocarcinoma | P | F | 60 | pT1 | pN0 | G2 | NA | Bc6 |
| CE2 | adenocarcinoma | D | F | 29 | pT2 | pN0 | G2 | NA | |
| CE3 | adenocarcinoma | D | M | 68 | pT2 | pN1a | G2 | NA | Bc2, LN3 |
| CE4 | adenocarcinoma | D | M | 70 | pT2 | pN0 | G2 | NA | |
| CE5 | adenocarcinoma | U | M | 51 | pT1 | pN0 | G1 | NA | |
| CE6 | adenocarcinoma | P | M | 62 | pT2 | pNx | G2 | NA | |
| CE7 | adenocarcinoma | P | M | 66 | pT2 | pN0 | G2 | NA | |
| CL1 | adenocarcinoma | D | F | 68 | pT4b | pN0 | G2 | NA | Bc1 |
| CL2 | adenocarcinoma | P | M | 71 | pT3 | pN2 | G2 | NA | Bc7 |
| CL3 | adenocarcinoma | D | M | 56 | pT3 | pN1a | G2 | NA | Bc3, LN4 |
| CL4 | adenocarcinoma | D | M | 61 | pT3 | pN2b | G2 | NA | Bc4, LN2 |
| CL5 | adenocarcinoma | D | M | 72 | pT3 | pN0 | G2 | NA | Bc5 |
| CL6 | adenocarcinoma | P | F | 70 | pT3 | pN1b | G3 | NA | |
| CL7 | adenocarcinoma | P | F | 69 | pT3 | pN1a | G2 | NA | |
| CL8 | adenocarcinoma | D | M | 61 | pT4b | pN1b | G3 | NA | |
| LN1 | metastatic adenocarcinoma | NA | M | 71 | pT3 | pN2b | G2 | lymph node | Bc7, CL2, AS7 |
| LN2 | metastatic adenocarcinoma | NA | M | 61 | pT3 | pN2b | G2 | lymph node | Bc4, CL4 |
| LN3 | metastatic adenocarcinoma | NA | M | 68 | pT2 | pN1a | G2 | lymph node | Bc2, CE3 |
| LN4 | metastatic adenocarcinoma | NA | M | 56 | pT4b | pN1a | G2 | lymph node | Bc3, CL3 |
| LN5 | metastatic adenocarcinoma | NA | M | 48 | pT3 | pN2b | G2 | lymph node | M6 |
| LN6 | metastatic adenocarcinoma | NA | M | 51 | pT4b | pN1a | G3 | lymph node | |
| LN7 | metastatic adenocarcinoma | NA | M | 58 | pT4b | pN1b | G2 | lymph node | |
| M1 | metastatic adenocarcinoma | NA | M | 59 | pT4b | pN2a | G3 | liver | |
| M2 | metastatic adenocarcinoma | NA | F | 61 | pT4a | pN1a | G2 | pelvic soft tissue | |
| M3 | metastatic adenocarcinoma | NA | F | 71 | pT4b | pN1b | G3 | liver | |
| M4 | metastatic adenocarcinoma | NA | F | 52 | pT4b | pNx | G2 | liver | |
| M5 | metastatic adenocarcinoma | NA | M | 58 | pT4b | pNx | G2 | liver | |
| M6 | metastatic adenocarcinoma | NA | M | 48 | pT3 | pN2b | G2 | liver | LN5 |
| M7 | metastatic adenocarcinoma | NA | M | 52 | pT3 | pN1 | G2 | liver | |
| *American Joint Committee on Cancer Cancer Staging Manual, 7th Ed. | |||||||||
| †P = proximal (cecum, ascending, transverse colon), D = distal (descending, sigmoid colon & rectum), U = unknown, N/A = not applicable | |||||||||