CHTN_CRC3 - Colorectal Carcinoma Progression

Code	Tissue type	# of cases*

Bnc	normal non-neoplastic colonic mucosa from non-cancer cases	7
Bc	normal non-neoplastic colonic mucosa from cancer cases	7
Bi	inflamed and/or regenerative non-neoplastic mucosa (ulcerative colitis)	7
AS	adenomas, < 2 cm in maximum dimension	7
AL	adenomas, > 2 cm in maximum dimension	7
CE	primary invasive adenocarcinoma, pathologic stage T1 or T2	7
CL	primary invasive adenocarcinoma, pathologic stage T3 or T4	7
LN	colorectal adenocarcinoma metastatic to lymph nodes, same cases as CL primary cancers	7
M	colorectal adenocarcinoma metastatic to distant sites	7

Con1	Spleen (control tissue)
Con2	Kidney (control tissue)
Con3	Placenta (control tissue)
Con4	Liver (control tissue)

*This number represents the number of cases selected in the original design of the TMA. Due to the non-uniformity inherent to tissue samples and histologic techniques, not all cases will be represented in all of the TMA sections. In quality assurance assessment of the TMA sections, a minimum of10 cases each of non-neoplastic mucosa, adenoma, primary carcinoma, and metastatic tumor must be present in at least one tissue spot.