CHTN2003CRCprog - Colorectal Carcinoma Progression

CHTN2003CRCprog - Colorectal Carcinoma Progression TMA Map

Code Key

Code Tissue type # of cases*
 
Bnc normal non-neoplastic colonic mucosa from non-cancer cases 7
Bc normal non-neoplastic colonic mucosa from cancer cases 7
Bi inflamed and or regenerative non-neoplastic mucosa (ulcerative colitis) 6
AS adenomas, < 2cm in maximum dimension 7
AL adenomas, > 2 cm in maximum dimension 7
CE primary invasive adenocarcinoma, pathologic stage T1 or T2 7
CL primary invasive adenocarcinoma, pathologic stage T3 or T4 7
LN colorectal adenocarcinoma metastatic to lymph nodes, same cases as CL primary cancers 7
M colorectal adenocarcinoma metastatic to distant sites 7
 
Con1 Spleen (control tissue)  
Con2 Kidney (control tissue)  
 

*This number represents the number of cases selected in the original design of the TMA. Due to the non-uniformity inherent to tissue samples and histologic techniques, not all cases will be represented in all of the TMA sections. In quality assurance assessment of the TMA sections, a minimum of10 cases each of non-neoplastic mucosa, adenoma, primary carcinoma, and metastatic tumor must be present in at least one tissue spot.

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Cases

TMA code Diagnosis Anatomic location of tissue sample Gender Age pT stage* N stage* metastatic site Other samples from same subject
Bnc1 diverticulosis D M 50 NA NA NA  
Bnc2 diverticulosis D M 74 NA NA NA  
Bnc3 diverticulosis P M 74 NA NA NA  
Bnc4 diverticulosis P M 69 NA NA NA  
Bnc5 diverticulosis D F 79 NA NA NA  
Bnc6 diverticulosis D M 40 NA NA NA  
Bnc7 diverticulosis D F 54 NA NA NA  
Bi1 ulcerative colitis U F 11 NA NA NA  
Bi2 ulcerative colitis P M 41 NA NA NA  
Bi3 ulcerative colitis D F 15 NA NA NA  
Bi4 ulcerative colitis D M 23 NA NA NA  
Bi5 ulcerative colitis P F 40 NA NA NA  
Bi6 ulcerative colitis D M 43 NA NA NA  
Bc1 mucosa adjacent to adenocarcinoma P M 63 T3 N2 NA CL1, LN1
Bc2 mucosa adjacent to adenocarcinoma D M 52 T3 N1 NA CL2, LN2
Bc3 mucosa adjacent to adenocarcinoma D M 62 T3 N2 NA CL3, LN3
Bc4 mucosa adjacent to adenocarcinoma P M 71 T3 N2 NA AS3, AL1,CL4, LN4
Bc5 mucosa adjacent to adenocarcinoma U F 51 T3 N2 NA AS4, CL5, LN5
Bc6 mucosa adjacent to adenocarcinoma P F 57 T3 N2 NA CL6, LN6
Bc7 mucosa adjacent to adenocarcinoma P F 42 T3 N1 NA CL7, LN7
AS1 tubular adenoma D M 48 NA NA NA AS5
AS2 tubular adenoma P F 59 NA NA NA  
AS3 tubular adenoma P M 71 NA NA NA BC4, AL1,CL4, LN4
AS4 tubular adenoma D F 51 NA NA NA BC5, CL5, LN5
AS5 tubular adenoma D M 48 NA NA NA AS1
AS6 tubular adenoma D M 71 NA NA NA  
AS7 tubular adenoma P M 58 NA NA NA  
AL1 tubulovillous adenoma P M 71 NA NA NA BC4, AS3,CL4, LN4
AL2 villous adenoma D M 67 NA NA NA  
AL3 villous adenoma P F 48 NA NA NA CE5
AL4 tubulovillous adenoma P M 58 NA NA NA CE7
AL5 tubulovillous adenoma U F 45 NA NA NA  
AL6 tubulovillous adenoma U F 70 NA NA NA  
AL7 tubulovillous adenoma P M 63 NA NA NA  
CE1 adenocarcinoma D M 67 T2 N1 NA  
CE2 adenocarcinoma D M 83 T2 N0 NA  
CE3 adenocarcinoma D M 67 T2 N1 NA  
CE4 adenocarcinoma P F 58 T1 N0 NA  
CE5 adenocarcinoma D F 48 T1 N0 NA AL3
CE6 adenocarcinoma P M 57 T2 N0 NA  
CE7 adenocarcinoma D M 58 T2 N0 NA AL4
CL1 adenocarcinoma P M 63 T3 N2 NA Bc1, LN1
CL2 adenocarcinoma D M 52 T3 N1 NA Bc2, LN2
CL3 adenocarcinoma D M 62 T3 N2 NA Bc3, LN3
CL4 adenocarcinoma P M 71 T3 N2 NA Bc4, AS3, AL1, LN4
CL5 adenocarcinoma D F 51 T3 N2 NA Bc5, AS4, LN5
CL6 adenocarcinoma P F 57 T3 N2 NA Bc6, LN6
CL7 adenocarcinoma P F 42 T3 N1 NA Bc7, LN7
LN1 adenocarcinoma NA M 63 T3 N2 lymph node Bc1, CL1
LN2 adenocarcinoma NA M 52 T3 N1 lymph node Bc2, CL2
LN3 adenocarcinoma NA M 62 T3 N2 lymph node Bc3, CL3
LN4 adenocarcinoma NA M 71 T3 N2 lymph node Bc4, AS3, AL1,CL4,
LN5 adenocarcinoma NA F 51 T3 N2 lymph node Bc5, AS4, CL5
LN6 adenocarcinoma NA F 57 T3 N2 lymph node Bc6, CL6
LN7 adenocarcinoma NA F 42 T3 N1 lymph node Bc7, CL7
M1 adenocarcinoma NA M 68 NA NA liver  
M2 adenocarcinoma NA M 51 NA NA liver  
M3 adenocarcinoma NA M 71 NA NA liver  
M4 adenocarcinoma NA F 52 NA NA liver  
M5 adenocarcinoma NA M 66 NA NA lung  
M6 adenocarcinoma NA M 71 NA NA lung  
M7 adenocarcinoma NA M 57 NA NA lung  
 
 
  *American Joint Committee on Cancer
  Cancer Staging Manual, 5th Ed.
 
  P = proximal (cecum, ascending, transverse colon), D = distal (descending, sigmoid colon & rectum), U = unknown, NA = not applicable

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